Polysorbate 80
Other names E433, Polysorbate
Polysorbate 80: low in FODMAPs. If you're sensitive to any of these, check it against your profile before eating.
Intolerances
- FODMAPsLow
Polysorbate 80 is the oleate version. Fat carries no fermentable carbohydrate, and the sorbitol in the sorbitan name is bound into the molecule rather than free - it is not released as the polyol that would matter here.
- LactoseFODMAPsNone
- Histamine (+liberators / DAO inhibitors)None
Polysorbate 80 (E433) has no histamine route: it neither contains nor releases histamine and does not inhibit DAO, so nothing on this axis reaches it. It deserves a line for a different reason — it is one of the two emulsifiers Chassaing tested in mice, where low concentrations produced low-grade inflammation and metabolic syndrome, and colitis in animals already predisposed. The route was the microbiota pushing into the mucus layer, and faecal transplants showed that change was enough on its own. Mice, not people, and a different mechanism from this axis — avoiding it will not lower a histamine load.
Sources· 2
- Chassaing B et al., Nature 519 (2015) 92-96, emulsifiers in mice
- Chassaing B et al., Gastroenterology 162 (2022) 743-756, controlled feeding of carboxymethylcellulose in healthy adults
- GlutenNo
- FructoseFODMAPsNone
- OligosaccharidesFODMAPsNone
- SorbitolFODMAPsNone
- SucroseNone
- TyramineNone
- SalicylateNone
- NickelNone
- OxalatesNone
Intolerance levels are based on our documented scientific sources. See sources →
React to FODMAPs? Check these too
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- Adipic acid
- Agar-agar
- Alginic acid
- Allura Red AC
- Alpha-tocopherol
Frequently asked questions
Which intolerances does Polysorbate 80 affect?
Polysorbate 80 is notable for FODMAPs. Clear on lactose, histamine, gluten, fructose, oligosaccharides, sorbitol, sucrose, tyramine, salicylate, nickel and oxalates.
Does Polysorbate 80 contain FODMAPs?
Polysorbate 80 contains only low levels of FODMAPs. Polysorbate 80 is the oleate version. Fat carries no fermentable carbohydrate, and the sorbitol in the sorbitan name is bound into the molecule rather than free - it is not released as the polyol that would matter here. Amounts vary by brand and recipe, so always check the label of the exact product.
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