Sodium Metabisulfite

Other names E223, E 223
Sodium Metabisulfite: high in histamine and salicylate. If you're sensitive to any of these, check it against your profile before eating.
Intolerances
- Histamine (+liberators / DAO inhibitors)High
Sodium metabisulfite is the sodium salt in its dimeric form, the one that turns up most often on a wine or dried-fruit label, and sulfites are not documented as inhibitors of DAO, the enzyme that clears histamine. Sulfites are here because their intolerance looks like histamine intolerance and travels in the same foods — not because a mechanism links them. If a label says sulphites without an E number, this is the most likely one. It behaves like the rest of the family: no histamine of its own, and a sensitivity that happens to travel in the foods this axis already covers.
Sources· 4
- Comas-Baste et al., Biomolecules 10:1181 (2020)
- Maintz & Novak, Am J Clin Nutr 2007
- Reg. (EU) No 1169/2011 Annex II for the 10 mg/kg declaration
- EFSA (2016), re-evaluation of sulfur dioxide and the sulfites, EFSA Journal 14(4):4438
- SalicylateHigh
Sodium Metabisulfite is a sulfite, which is a separate intolerance from salicylate, but the two are so often eliminated together — and so often co-present in dried fruit and wine — that it is flagged on this axis.
Sources· 1
- Baenkler H-W., Dtsch Arztebl Int 105:8 (2008) 137-142, salicylate intolerance - mechanism, clinical spectrum, diagnosis and treatment
- TyramineNone
- SucroseNone
- FODMAPsNone
- LactoseFODMAPsNone
- OligosaccharidesFODMAPsNone
- SorbitolFODMAPsNone
- FructoseFODMAPsNone
- NickelNone
- OxalatesNone
- GlutenNo
Intolerance levels are based on our documented scientific sources. See sources →
React to Histamine (+liberators / DAO inhibitors)? Check these too
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Frequently asked questions
Which intolerances does Sodium Metabisulfite affect?
Sodium Metabisulfite is notable for histamine and salicylate. Clear on tyramine, sucrose, FODMAPs, lactose, oligosaccharides, sorbitol, fructose, nickel, oxalates and gluten.
Does Sodium Metabisulfite contain histamine?
Yes — Sodium Metabisulfite is high in histamine. Sodium metabisulfite is the sodium salt in its dimeric form, the one that turns up most often on a wine or dried-fruit label, and sulfites are not documented as inhibitors of DAO, the enzyme that clears histamine. Sulfites are here because their intolerance looks like histamine intolerance and travels in the same foods — not because a mechanism links them. If a label says sulphites without an E number, this is the most likely one. It behaves like the rest of the family: no histamine of its own, and a sensitivity that happens to travel in the foods this axis already covers.
Does Sodium Metabisulfite contain salicylate?
Yes — Sodium Metabisulfite is high in salicylate. Sodium Metabisulfite is a sulfite, which is a separate intolerance from salicylate, but the two are so often eliminated together — and so often co-present in dried fruit and wine — that it is flagged on this axis. Amounts vary by brand and recipe, so always check the label of the exact product.
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