Sodium bisulfite
Other names sodium bisulphite, E222
Sodium bisulfite: high in histamine. If you're sensitive to any of these, check it against your profile before eating.
Intolerances
- Histamine (+liberators / DAO inhibitors)High
Sodium bisulfite is the same sodium salt in its hydrogen form, and sulfites are not documented as inhibitors of DAO, the enzyme that clears histamine. Sulfites are here because their intolerance looks like histamine intolerance and travels in the same foods — not because a mechanism links them. Nothing separates it from the others in how it acts here, which is to say it acts on nothing here: the sensitivity is real and the mechanism is not shared.
Sources· 4
- Comas-Baste et al., Biomolecules 10:1181 (2020)
- Maintz & Novak, Am J Clin Nutr 2007
- Reg. (EU) No 1169/2011 Annex II for the 10 mg/kg declaration
- EFSA (2016), re-evaluation of sulfur dioxide and the sulfites, EFSA Journal 14(4):4438
- TyramineNone
- SalicylateNone
- SucroseNone
- FODMAPsNone
- LactoseFODMAPsNone
- OligosaccharidesFODMAPsNone
- SorbitolFODMAPsNone
- FructoseFODMAPsNone
- NickelNone
- OxalatesNone
- GlutenNo
Intolerance levels are based on our documented scientific sources. See sources →
React to Histamine (+liberators / DAO inhibitors)? Check these too
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Frequently asked questions
Which intolerances does sodium bisulfite affect?
Sodium bisulfite is notable for histamine. Clear on tyramine, salicylate, sucrose, FODMAPs, lactose, oligosaccharides, sorbitol, fructose, nickel, oxalates and gluten.
Does sodium bisulfite contain histamine?
Yes — sodium bisulfite is high in histamine. Sodium bisulfite is the same sodium salt in its hydrogen form, and sulfites are not documented as inhibitors of DAO, the enzyme that clears histamine. Sulfites are here because their intolerance looks like histamine intolerance and travels in the same foods — not because a mechanism links them. Nothing separates it from the others in how it acts here, which is to say it acts on nothing here: the sensitivity is real and the mechanism is not shared. Amounts vary by brand and recipe, so always check the label of the exact product.
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