Ponceau 4R

Other names E124, Cochineal Red A
Ponceau 4R: moderate in histamine and salicylate; low in FODMAPs and oligosaccharides. If you're sensitive to any of these, check it against your profile before eating.
Intolerances
- Histamine (+liberators / DAO inhibitors)Moderate
Ponceau 4R (E124) is the red of tinned strawberries, packet trifles and cheap salami casings, and it is the fifth of the Southampton colours present in this catalogue - so it too carries the children's attention warning. It holds no histamine itself, and the liberator label it carries here is the elimination protocols' classification rather than a measured effect. The Swiss list rates it 2 of 3 and marks it L, its letter for liberators of mast cell mediators — a presumed reason rather than a measurement.
Sources· 4
- Zuberbier et al., EAACI/GA2LEN urticaria guideline
- EFSA re-evaluations of food colours (2009-2016)
- Reg. (EC) 1333/2008 Annex V
- SIGHI — Swiss Interest Group Histamine Intolerance, food-compatibility list (2024-08-29), for the L classification and the compatibility rating
- SalicylateModerate
An azo dye used for red shades, in the same group as tartrazine — the synthetic colours with a long-documented cross-reaction in salicylate and aspirin sensitivity. It is also one of the six colours of Annex V of the additives regulation, which must carry the children's attention warning on the label - a different endpoint from this axis: attention, not salicylate.
Sources· 2
- Baenkler H-W., Dtsch Arztebl Int 105:8 (2008) 137-142, salicylate intolerance - mechanism, clinical spectrum, diagnosis and treatment
- Regulation (EC) No 1333/2008, Article 24 and Annex V — the six colours whose presence requires the children's attention warning on the label
- FODMAPsLow
Ponceau 4R is a synthetic red dye, and there is no fermentable carbohydrate in it.
Sources· 1
- Gibson P.R. & Shepherd S.J., J Gastroenterol Hepatol 25 (2010) 252-258, the framework this axis rests on
- OligosaccharidesFODMAPsLow
Ponceau 4R is an azo dye - a synthetic aromatic molecule with no sugar unit anywhere in it - used in milligrams. It sits at low rather than none because the additive category is reviewed as a block, not because an oligosaccharide was found in it.
- LactoseFODMAPsNone
- GlutenNone
- FructoseFODMAPsNone
- SorbitolFODMAPsNone
- SucroseNone
- TyramineNone
- NickelNone
- OxalatesNone
Intolerance levels are based on our documented scientific sources. See sources →
Note about this food
Ponceau 4R is classified as a histamine liberator, meaning it can trigger the release of endogenous histamine from mast cells without containing histamine itself . This can cause pseudo-allergic reactions in sensitive individuals, potentially intensifying asthma symptoms
React to Histamine (+liberators / DAO inhibitors)? Check these too
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Frequently asked questions
Which intolerances does ponceau 4R affect?
Ponceau 4R is notable for histamine, salicylate, FODMAPs and oligosaccharides. Clear on lactose, gluten, fructose, sorbitol, sucrose, tyramine, nickel and oxalates.
Does ponceau 4R contain histamine?
Ponceau 4R contains moderate levels of histamine. Ponceau 4R (E124) is the red of tinned strawberries, packet trifles and cheap salami casings, and it is the fifth of the Southampton colours present in this catalogue - so it too carries the children's attention warning. It holds no histamine itself, and the liberator label it carries here is the elimination protocols' classification rather than a measured effect. The Swiss list rates it 2 of 3 and marks it L, its letter for liberators of mast cell mediators — a presumed reason rather than a measurement.
Does ponceau 4R contain salicylate?
Ponceau 4R contains moderate levels of salicylate. An azo dye used for red shades, in the same group as tartrazine — the synthetic colours with a long-documented cross-reaction in salicylate and aspirin sensitivity. It is also one of the six colours of Annex V of the additives regulation, which must carry the children's attention warning on the label - a different endpoint from this axis: attention, not salicylate.
Does ponceau 4R contain FODMAPs?
Ponceau 4R contains only low levels of FODMAPs. Ponceau 4R is a synthetic red dye, and there is no fermentable carbohydrate in it.
Does ponceau 4R contain oligosaccharides?
Ponceau 4R contains only low levels of oligosaccharides. Ponceau 4R is an azo dye - a synthetic aromatic molecule with no sugar unit anywhere in it - used in milligrams. It sits at low rather than none because the additive category is reviewed as a block, not because an oligosaccharide was found in it. Amounts vary by brand and recipe, so always check the label of the exact product.
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