Calcium diglutamate
Other names E623
Calcium diglutamate: moderate in histamine. If you're sensitive to any of these, check it against your profile before eating.
Intolerances
- Histamine (+liberators / DAO inhibitors)Moderate
Calcium diglutamate (E623) carries two glutamate molecules per calcium, and it is used where neither sodium nor potassium is wanted. It is rare on European labels. Standing unchanged: no established mechanism, kept in the protocols by convention. EFSA set the first ADI for these additives at 30 mg per kilo of body weight a day, then found exposure above it — and above DOSES ASSOCIATED WITH ADVERSE EFFECTS IN HUMANS — for some population groups. That answers a different question from the blinded challenge: habitual intake, not a meal. Glutamate is not histamine, and the body does not make histamine from it - histamine comes from histidine. It is on this page because the elimination protocols remove the flavour enhancers alongside the colours and the preservatives.
Sources· 3
- Geha et al., J Nutr 2000 (multicentre DBPC MSG trial)
- EFSA re-evaluation of glutamates, 2017
- EFSA Panel on Food Additives (2017), re-evaluation of glutamic acid (E 620) and the glutamates (E 621-E 625) as food additives
- TyramineNone
- SalicylateNone
- SucroseNone
- FODMAPsNone
- LactoseFODMAPsNone
- OligosaccharidesFODMAPsNone
- SorbitolFODMAPsNone
- FructoseFODMAPsNone
- NickelNone
- OxalatesNone
- GlutenNo
Intolerance levels are based on our documented scientific sources. See sources →
React to Histamine (+liberators / DAO inhibitors)? Check these too
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Frequently asked questions
Which intolerances does calcium diglutamate affect?
Calcium diglutamate is notable for histamine. Clear on tyramine, salicylate, sucrose, FODMAPs, lactose, oligosaccharides, sorbitol, fructose, nickel, oxalates and gluten.
Does calcium diglutamate contain histamine?
Calcium diglutamate contains moderate levels of histamine. Calcium diglutamate (E623) carries two glutamate molecules per calcium, and it is used where neither sodium nor potassium is wanted. It is rare on European labels. Standing unchanged: no established mechanism, kept in the protocols by convention. EFSA set the first ADI for these additives at 30 mg per kilo of body weight a day, then found exposure above it — and above DOSES ASSOCIATED WITH ADVERSE EFFECTS IN HUMANS — for some population groups. That answers a different question from the blinded challenge: habitual intake, not a meal. Glutamate is not histamine, and the body does not make histamine from it - histamine comes from histidine. It is on this page because the elimination protocols remove the flavour enhancers alongside the colours and the preservatives. Amounts vary by brand and recipe, so always check the label of the exact product.
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