Carboxymethylcellulose
Other names E466, Cellulose gum
Carboxymethylcellulose: no notable intolerance on record.
Intolerances
- FODMAPsNone
- LactoseFODMAPsNone
- Histamine (+liberators / DAO inhibitors)None
Carboxymethylcellulose (E466) has no histamine route — no histamine in it, none released, no effect on DAO — so nothing on this axis reaches it. It has been fed to people in a controlled trial for this question: sixteen healthy adults, eleven days, 15 grams a day against an identical emulsifier-free diet. Those eating it reported modestly more abdominal discomfort after meals, and their gut microbiota lost diversity while faecal short-chain fatty acids fell. Sixteen people at a dose far above ordinary intake is a small, strong signal about a different mechanism — not this axis.
Sources· 2
- Chassaing B et al., Nature 519 (2015) 92-96, emulsifiers in mice
- Chassaing B et al., Gastroenterology 162 (2022) 743-756, controlled feeding of carboxymethylcellulose in healthy adults
- GlutenNo
- FructoseFODMAPsNone
- OligosaccharidesFODMAPsNone
- SorbitolFODMAPsNone
- SucroseNone
- TyramineNone
- SalicylateNone
- NickelNone
- OxalatesNone
Intolerance levels are based on our documented scientific sources. See sources →
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Frequently asked questions
Which intolerances does Carboxymethylcellulose affect?
No notable intolerance on record. Clear on FODMAPs, lactose, histamine, gluten, fructose, oligosaccharides, sorbitol, sucrose, tyramine, salicylate, nickel and oxalates.
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